Andrew Weeden presents poster detailing KP/RiboMHC mouse model efficacy for RPF profiling

Andrew Weeden presenting "Engineering A New Mouse Model To Study Translational Dynamics And Antigen Presentation In Vivo"

At the RNA Processing in Cancer conference, Research Technician Andrew Weeden presented a poster discussing our lab's use of mouse models to investigate tumor specific translation in vivo.

By inducing a ribosomal tag exclusively in tumor cells, our lab is able to isolate actively translating ribosomes specific to tumor cells . We can then sequence the ribosome protected fragments of RNA (RPFs) to determine which genes are being actively translated in tumor cells.

This novel method of observing tumor specific translation in vivo allows us to investigate a multitude of questions from the relationship between translation and MHC-peptide presentation, to effects of pharmaceutical treatments.